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Welcome to the Midrin Forum

I find that for a not too severe migraine this seems to be a rather under-rated drug. It has far less side effects than the triptans at a fraction of their cost.

As far as I know, Midrin is no longer available. Teri Robert and I were discussing whether it was legal for compounders to make it. Neither of us was sure.

I saved back a couple of doses worth because I do agree with you Gregory – while it didn’t always do 100% of the job and was not so good for a real whopper, sometimes using it in combination was helpful to me personally. It definitely was one that, since I can’t take Triptans any longer, I could take immediately as soon as I knew I was headed for trouble and it would often stop things before they got too out of control. I always had to take the max dose, but so long as it worked I was okay with that.

I’m not actually even for sure why this isn’t available anymore. It’s a shame though.

Teri Robert wrote an about Midrin being discontinued: http://www.helpforheadaches.com/articles/2010/Discontinued-Migraine-Medications.htm.

I agree with both of you – it didn’t completely eliminate the migaine pain, but it was better than nothing. The Triptans don’t work at all for me. I was maxing out my Midrin usage, so my neurologist changed me to a different abortive medication. But, it works about as well as the Midrin did… and, he said that this is the last medicine option he has (he actually said that he’s out of ideas/options). I agree, Ellen, it’s a shame that it’s not available anymore.

These medications were developed before the current FDA approval process was put into place. Manufacturers have had years to apply for FDA approval, bu none had, so the manufacturers discontinued making them to comply with FDA regulations. I’ve been working to find out if any of them are going to be back, and the good news is that Epidrin will probably be back by early spring. You can read a full update as of today (Jan. 16) at http://www.puttingourheadstogether.com/2011/01/migraine-and-medications-like-midrin-11611-update.html.

Hope this is helpful!

Yes Teri – I was so hoping you’d have something helpful to add… Thank you so much

I do not know where you are located , but I have had absolutely no problem obtaining the Epidrin (Midrin equivalent) here in Florida, at my Publix pharmacy. I have been getting the script filled monthly without any delays.nI was very surprised when I started reading about it reportedly being discontinued. I have been on it (approx 8 months).

Gregory,

Whatever Epidrin is in stock right now is all there will be for a probably short while. They are not shipping it at this time. They have temporarily stopped shipping while they apply for FDA approval of Epidrin.

You can find more details at http://www.puttingourheadstogether.com/2011/01/migraine-and-medications-like-midrin-11611-update.html.

Teri

Teri, I’m glad to hear that Epidrin might become available again. I hope I won’t need to take it in the future, but it’s a medication that helped to the same degree as the one I’m on now. Thank you for the update.

I just got another refill today. Maybe I should try to start building up a back log of it while I can .

Gregory,

If you can, it wouldn’t hurt to fill it now while your pharmacy has it. Excellium is applying for FDA approval, but you never know how long it will take.

Well I just got the last 20 Epidrin my Publix pharmacy had…I guess that is the last of it. I understand the FDA approval will not be forthcoming.

Sorry, Gregory.

There are a couple of options. Prodrin contains isometheptene mucate and acetaminophen like Epidrin did, but not the sedative ingredient. It has caffeine instead. It’s still being made and shipped. You can also get a prescription to take to a compounding pharmacy.

Want to let everyone know that I am a compounding pharmacist and I can compound Midrin (Isometheptene Mucate, Dichlorophenazone, aceteminophen). This is perfectly legal. I am a pharmacist compounding upon receipt of a written prescription for a specific person, not a bulk manufacturer and therefore I am not subject to FDA rules/regs on manufacturing.

Where are you located ? And do you know how costly it would be to have Midrin compounded ? Greg